Anomalous responses of tumor vasculature to norepinephrine and prostaglandin E2 in the rabbit.
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چکیده
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منابع مشابه
Modification by prostaglandins E1 and E2, indomethacin, and arachidonic acid of the vasoconstrictor responses of the isolated perfused rabbit and rat mesenteric arteries to adrenergic stimuli.
In isolated perfused rabbit mesenteric arteries, prostaglandin (PG) E1 and E2, 1-5NG/ML, did not alter the basal perfusion pressure, but reduced the vasoconstrictor responses to sympathetic nerve stimulation; the responses to injected norepinephrine were reduced by PGE1 and variably affected by PGE2. In contrast, in rat mesenteric arteries PGE1 and PGE2, 1-5 ng/ml, potentiated the vasoconstrict...
متن کاملModulation by prostaglandins of adrenergic transmission in the isolated perfused rabbit and rat kidney.
In the isolated perfused rabbit kidney prostaglandins (PGS) E1 (0.02-0-1 ng/ml), E2 (0.02-0.1 ng/ml), and A2 (1-5 ng/ml) inhibited the vasoconstrictor responses to sympathetic nerve stimulation by 21-44%, 31-39%, and 20-23%, respectively, without alerting those to injected norepinephrine. In contrast, in the rat kidney PGE1 (0.5 ng/ml), PGE2 (0.5 ng/ml), and PGA2 (5 ng/ml) enhanced the vasocons...
متن کاملModification by Prostaglandins Ex and E2, Indomethacin, and Arachidonic Acid of the Vasoconstrictor Responses of the Isolated Perfused Rabbit and Rat Mesenteric Arteries to Adrenergic Stimuli
In isolated perfused rabbit mesenteric arteries, prostaglandin (PG) E, and E,, 1-5 ng/ml, did not alter the basal perfasion pressure, but reduced tbe vasoconstrictor responses to sympathetic nerve stimulation; the responses to injected Borepinephrine were reduced by PGE, and TariaMy affected by PGE,. In contrast, in rat mesenteric arteries PGE, and PGE,, 1-5 ng/ml, potentiated the vasoconstrict...
متن کاملInfluence of prostaglandin E2, indomethacin, and reserpine on renal vascular responses to nerve stimulation, pressor and depressor hormones.
The effects of prostaglandin E2 (PGE2) indomethacin, and reserpine were evaluated in the rabbit renal vascular bed in situ under conditions of controlled blood flow. Intrarenal infusion of PGE2, 0.03 and 0.3 microgram/min, decreased responses to renal nerve stimulation, intra-arterial norepinephrine, and angiotensin. Responses to nerve stimulation were decreased to a greater extent than respons...
متن کاملAdrenergic Stimuli
In isolated rat spleen perfused with Tyrode's solution, prostaglandin (PG) Ei and E2, 0.2-2.5 ng/ml, reduced the vasoconstrictor responses to sympathetic nerve stimulation by 38-89% and 35-73% and to injected norepinephrine by 18-53% and 18-34%, respectively. In contrast, PGF2o and thromboxane B2 (TXB2) produced vasoconstriction and potentiated the vascular responses to both adrenergic stimuli,...
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عنوان ژورنال:
- Circulation research
دوره 41 4 شماره
صفحات -
تاریخ انتشار 1977